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Diagnostics

Menstrual blood contains hormones (estradiol, progesterone), metabolic markers (triglycerides, HbA1c), vitamins (A and D), and inflammatory cytokines at levels that correlate strongly with venous blood, supporting its use as a clinically relevant sample for systemic and reproductive health monitoring. Recent studies show that menstrual blood can be used to non‑invasively detect and monitor conditions such as endometriosis, unexplained infertility, female genital tract tuberculosis, and cervical cancer by assaying genetic, proteomic, and immune biomarkers specific to endometrial pathology. Wearable or pad‑integrated devices have already demonstrated accurate detection of HbA1c and other analytes directly from menstrual blood, illustrating the feasibility of at‑home, repeated diagnostic testing without venipuncture.

Biologics

Menstrual fluid contains a rich mix of endometrial epithelial cells, stromal cells, mesenchymal stromal/stem cells (MenSCs), vascular cells, and diverse immune populations (including T cells, NK cells, macrophages), which retain transcriptomic features highly similar to cells from endometrial biopsies. MenSCs isolated from menstrual blood show mesenchymal stem cell–like properties (CD73⁺, CD90⁺, CD105⁺, multi‑lineage differentiation) and exhibit potent immunomodulatory effects on NK, T, B, and myeloid cells, offering a window into local immune regulation as well as a promising cell source for regenerative and immunotherapy research. Studies comparing MenSCs from people with and without endometriosis reveal differences in proliferation, invasion, adhesion, and expression of immunomodulatory molecules, indicating that menstrual blood–derived cells can capture disease‑specific biological signatures not evident in peripheral blood alone. In addition, extracellular vesicles isolated from menstrual blood serum carry distinct molecular cargo in fertile versus infertile individuals with unexplained infertility, suggesting a novel class of non‑invasive biomarkers that reflect endometrial function and implantation potential.

Research

Large‑scale, population‑level menstrual data—whether from physical samples or digital cycle tracking—are transforming research on menstrual and reproductive health by enabling robust epidemiologic studies of heavy menstrual bleeding, cycle variability, and gynecologic disease burden. Genome‑wide association studies of heavy menstrual bleeding and integrated analyses of de‑identified app‑based tracking data have already linked menstrual phenotypes to genetic variants and quality‑of‑life outcomes, underscoring how aggregated menstrual information can reveal patterns that individual clinical encounters may miss. Emerging multi‑omic and single‑cell studies of menstrual fluid, including home‑collected samples profiled by scRNA‑seq, are building reference atlases of endometrial and immune cell states that will support development of more precise diagnostics and targeted therapies for conditions like endometriosis, infertility, and abnormal uterine bleeding.

Our Partners

• Academic Labs at UC Berkeley, UCSF, MIT
• Femtech Startups: Muse Bio, Opal Therapeutics, Cove Cups

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Optimize Your Workouts

Your menstrual cycle creates a shifting hormonal landscape that directly affects muscle performance, energy availability, and recovery. During the follicular phase (days 1–14), rising estrogen enhances muscle force production, increases pain tolerance, and improves neuromuscular coordination—making it the ideal window for high‑intensity strength training, HIIT, and pushing for personal records. Estrogen also supports collagen synthesis and joint stability, so heavy compound lifts and plyometrics are well‑tolerated here. As you approach ovulation, peak estrogen and a surge in luteinizing hormone provide a natural performance boost—many athletes report their best lifts and fastest sprint times around days 12–14. In the early luteal phase (days 15–21), rising progesterone elevates core body temperature and shifts fuel utilization toward fat oxidation, making moderate‑intensity steady‑state cardio, tempo runs, and endurance work feel more natural. During the late luteal and menstrual phase, when both hormones dip, prioritize active recovery, mobility work, yoga, and lighter volume to support recovery without overtaxing a system under hormonal flux.

Optimize Your Nutrition

Hormonal shifts across the cycle change your metabolic rate, micronutrient needs, and appetite signals. In the follicular phase, insulin sensitivity is higher, meaning your body handles carbohydrates more efficiently—this is a great time to fuel intense training with complex carbs (oats, sweet potatoes, whole grains) and lean protein to support muscle protein synthesis driven by rising estrogen. Around ovulation, bump up anti‑inflammatory foods rich in omega‑3s (salmon, walnuts, flaxseed) and antioxidants (berries, leafy greens) to counteract the mild inflammatory response that accompanies the LH surge. In the luteal phase, basal metabolic rate increases by roughly 100–300 calories per day, so honor increased hunger with nutrient‑dense additions rather than restricting intake. Progesterone also promotes water retention and can drive cravings for magnesium‑rich foods—dark chocolate, avocados, and pumpkin seeds are excellent choices. Prioritize iron‑rich foods (red meat, lentils, spinach) paired with vitamin C during menstruation to replenish losses, and consider calcium and vitamin D supplementation in the luteal phase, where these nutrients can help ease PMS symptoms like mood swings and bloating.

Optimize Your Productivity

The same hormones that shape your physical performance also govern cognitive function, creativity, and emotional resilience. During the follicular phase, rising estrogen increases dopamine and serotonin activity, sharpening verbal fluency, working memory, and creative thinking—schedule brainstorming sessions, strategic planning, and learning new skills here. The days around ovulation bring peak communication and social confidence thanks to high estrogen and testosterone, making it ideal for presentations, negotiations, networking events, and collaborative projects. In the early luteal phase, progesterone's calming effect supports deep focus and detail‑oriented work—use this window for editing, analytical tasks, financial planning, and execution on established plans. As the late luteal phase arrives and both hormones decline, energy and concentration may wane; lean into administrative tasks, reflection, journaling, and planning for the next cycle. By aligning demanding cognitive work with your hormonal peaks and reserving lower‑stakes tasks for the premenstrual window, you can work with your biology instead of against it—boosting sustained productivity while reducing burnout.